Vesicle tumbling inhibited by inertia

Vesicle tumbling inhibited by inertia

Extracellular vesicle budding is inhibited by redundant regulators of TAT-5 flippase localization and phospholipid asymmetry

Cells release extracellular vesicles (EVs) that mediate intercellular communication and repair damaged membranes. Despite the pleiotropic functions of EVs in vitro, their in vivo function is debated, largely because it is unclear how to induce or inhibit their formation. In particular, the mechanisms of EV release by plasma membrane budding or ectocytosis are poorly understood. We previously sh...

Tumbling and technicolor theory.

The extended technicolor theory is a candidate of the physics beyond the standard model. To explain the mass hierarchy of the quarks and leptons, the extended technicolor gauge symmetry must hierarchically break to the technicolor gauge symmetry. Tumbling gauge theory is considered as a candidate of the dynamics of such hierarchical symmetry breaking, since the sequential self-breaking of the g...

Tumbling Political Theory

Blogging in the classroom is not a new idea, but my students have tended to view the blogging assignment negatively, as a homework assignment that simply needed to be done each week and then forgotten until the next time they were required to visit the blog. With that in mind, I decided to employ a very different method of educational blogging—using the Tumblr platform—in which each student wou...

Rotational propulsion enabled by inertia.

The fluid mechanics of small-scale locomotion has recently attracted considerable attention, due to its importance in cell motility and the design of artificial micro-swimmers for biomedical applications. Most studies on the topic consider the ideal limit of zero Reynolds number. In this paper, we investigate a simple propulsion mechanism --an up-down asymmetric dumbbell rotating about its axis...